In Vivo Neuroscience
CNS Disease Models and Safety Pharmacology Testing
WuXi Biology and Testing offers a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests to the evaluation of abuse and dependence liability and proconvulsant risk using EEG.
Our experts provide animal models in all areas of psychopharmacology, cognition, epilepsy and neurodegenerative disorders.
Our CNS Models
- Neurodegenerative Diseases
- Neuropsychiatric Disease
- Pain and Migraine
- Ocular Disease
- Otologic Disease
- Other Disease (Seizure, Sleep Disorders, Stroke, Neuromuscular Disease)
In Vivo Models for Neurodegenerative Diseases
Alzheimer’s Disease (AD) Models
- APP/PS1 transgenic mouse
- APPSWE transgenic mouse
- 5x FAD transgenic mouse
- Streptozotocin (STZ) induction, sporadic
- Aβ Oligomer-ICV/Hippocampal Parenchymal Injection Model
- hTau transgenic mouse
- Hypoxia exposure induced BBB Breakdown mouse
- ARIA model
- LPS or Low body temperature induced acute tau phosphorylation model
- LTP/LTD recording
- Goto-Kakizaki (GK) type 2 diabetes rat, aged
- Scopolamine induced cognitive impairment rat, aged
Parkinson’s Disease (PD) Models
- 6-hydroxydopamine (6-OHDA) induction, Mouse/Rat
- Rotenone induction, Mouse/Rat
- AAV alpha-synuclein overexpression/preformed fibril (PFF), Mouse/Rat
- AAV hA53T alpha-synuclein overexpression, Mouse/Rat
- MPTP induction, Mouse
- LRRK2*G2019Stransgenic mouse
- SNCA transgenic mouse
Huntington’s Disease Model
- BACHD transgenic mouse
- mHTT130 transgenic mouse
Multiple Sclerosis Model
Endpoints:
- MOG-induced EAE: clinical score, incidence, and inflammation response
- MBP-induced EAE: body weight, clinical score, and incidence rate
- Cuprizone model: grip test, ledged beam test, and myelin staining
Age-Dependent Neurodegeneration
- Senescence accelerated mouse (SAMP8)
- Aged C57BL/6J
Neurology
Our neurology models include seizure, dementia, autism, and traumatic brain injury. Also included are stroke models for middle cerebral artery occlusion (MCAO) and MCAO reperfusion models for rats, as well as the Ischemia model (Forebrain ischemia model in rats and gerbils).
Neuropsychiatric Diseases
By combining experience and expertise from both the pharmaceutical industry and academia, we provide valuable services to accelerate drug discovery for the treatment of psychiatric diseases and mental disorders.
Depression
- Chronic unpredictable mild stress (CUMS), Mouse/Rat
- Chronic social defeat stress (CSDS), Mouse
- Chronic corticosterone (CORT) induction, Mouse
- LPS induction, Mouse
- Chronic pain induction, Rat
Schizophrenia
- MK801/PCP-induced hyperlocomotion, positive symptoms， Mouse/Rat
- D-AMPH/METH/APO-induced hyperlocomotion, positive symptoms, Mouse/Rat
- Scopolamine-induced hyperlocomotion, positive symptoms, Mouse/Rat
- DOI/LSD/psilocybin-induced head twitch response, positive symptoms, Mouse
- APO-induced climbing, positive symptoms, Mouse
- Sub-chronic PCP induced social deficits, negative symptoms, Mouse
- Caffeine induced hyperlocomotion, positive symptoms, Mouse
- D-APMH-induced prepulseinhibition (PPI) deficits, Rat
- Ketamine-induced prepulseinhibition (PPI) deficits, Rat
- Scopolamine-induced prepulseinhibition (PPI) deficits, Rat
- Sub-chronic PCP-induced attentional set-shifting deficits test (ED/ID test), Rat
Autism Spectrum Disorder (ASD)
- NEU-C03-1 | Autism spectrum disorder (ASD) Model | Shank +/-
- BTBR mouse
- Methylimidazole induced anosmia, MouseFmr1-/y mouse.
Addiction
- Cocaine/ Morphine-conditioned place preference (CPP), Mouse/Rat
- Ketamine/Fentanyl conditioned place preference (CPP), Rat
- CB-1 agonist/Nicotine/Ketamine/Cocaineself administration (SA), Rat
- Intermittent access to 2-bottle choice (IA2BC) of alcohol drinking, Rat
- Ethanol-induced behavioral sensitization (BS), Mouse
Ocular Diseases
- Dry Age-Related Macular Degeneration (dAMD)
- Wet Age-Related Macular Degeneration (wAMD)
- Myopia
- Glaucoma
- Retinitis Pigmentosa
- Dry Eye
- Corneal defect
- Conjunctivitis
- Uveitis
- Presbyopia
- Diabetic Retinopathy
- Neurotrophic Keratitis
- Thyroid Eye Disease
Otologic Diseases
- Hearing Loss and Vestibular Dysfunction
- Hearing Loss
- Ocular Degeneration
- Surgery and chemical
- Physical induction
- Transgenic model
Motor Neuron Diseases
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
- B6SJL-Tg(SOD1*G93A)1Gur/J, Mouse
- C57BL/6JGpt-Tg(hSOD1 G93A,hSOD1)61/Gpt, Mouse
- B6;SJL-Tg(Thy1-TARDBP)4Singh/J, Mouse
- NTac: SD-Tg(SOD1G93A)L26H, Rat
Electrophysiology
- Electrogram
- Evoke potential
- Nerve conduction velocity
- Auditory brainstem response
- Vestibule-ocular reflex
- Telemetry
- Muscle strength test
- Ex vivo test
Behavioral Studies
Learning and memory
- Morris water maze
- Spatial learning and memory, working memory, reference memory, reversal learning, hippocampus-dependent memory
- Barnes maze
- Spatial learning and contextual conditioning (hippocampus-dependent)
- Cued conditioning (hippocampus-independent)
- Long-term memory, short-term memory, amygdala-dependent memory, fear response
Motor function
- Rotarod test
- Open-field test
- Walking-beam test
- Treadmill test (under development)
Anxiety-like behavior
- Elevated-plus maze
- Fear-conditioning test
- Open-field behavior
- Startle response
- Social interaction
Depression-like behavior
- Novelty-induced hypophagia
- Tail suspension test
- Forced swim test
- Open-field behavior
- Social interaction
- Learned helplessness
Schizophrenia/bipolar-like behavior
- Working memory
- Locomotion/motor activity
- Social interaction
- Aggressive/mania-like behavior
- Forced swim test
- Nesting behavior
- Pre-pulse inhibition (PPI) under development
Home cage behavior and environmental enrichment
Pain-related behavior
- Hot-plate
- Tail flick (infrared heat/pressure)
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