Large Animal Disease Models
Integrated Services Facilitate Translational Research
Large animal species are indispensable for translational research, particularly when small species inadequately model complex anatomy, physiology, target biology, or procedural requirements. They facilitate comprehensive preclinical evaluations of pharmacodynamic responses, efficacy, and target engagement, driving critical development-relevant endpoints.
WuXi Biology provides disease-centric pharmacology services featuring:
- Diverse Therapeutic Coverage: Validated models spanning key disease areas, including metabolism, cardiovascular, immunology, neurobiology, ophthalmology, and aging.
- Translational Imaging Modalities: Advanced in vivo imaging including DEXA, CT/PET-CT, MRI/MRI-PDFF, ultrasound, elastography, and x-ray.
- Fully Integrated Testing: Comprehensive analytical endpoints encompassing clinical pathology, PD biomarker evaluation, immune and multi-omics profiling, and histopathology.
State-of-the-Art Large Animal Facilities
Multi-Species Capacity
Our 10,000 + m² of IACUC-accredited housing accommodates non-human primates (Cynomolgus and Rhesus), minipigs, and dogs.
Advanced Biosafety Standards
Our fully equipped ABSL2 and BSL2 laboratories are operated by veterinary professionals dedicated to the highest standards of animal welfare.
One-Stop Service Platform
Our dedicated, disease-centric teams deliver tailored PD and efficacy testing across all developmental stages.
Ex Vivo Laboratory Services
PD/Immune Profiling Assessment
PD Biomarker Analysis
- Over 60 validated biomarkers
- More than 5 types of validated animal tissues
- Includes 4 large animal species
Immune Profiling
- 14 types of tissues digestion methods
- 21 colors in a single panel
- Analysis of over 17 immune cell subpopulations
Large Animal Histopathology
- Anatomy
- H&E/special staining/IHC/multiplex IF/ RNAscope
- TMA macrodissection/microdissection
- Board-certified veterinary pathologists
- Pathological evaluation, including drug-induced toxicity diagnosis of animal disease
- NHP tissue bank
Explore Solutions for Your Program
Explore solutions by development phase, drug modality, therapeutic area, or integrated discovery needs.
You May Also Be Interested In
Get a Quote
Ready to plan your next study? Share your program needs with our team for a tailored estimate.