Ophthalmic Toxicology | WuXi Biology & Testing

Advanced Ocular Toxicology and Toxicokinetics

Using the most advanced ocular toxicology evaluation techniques, the staff working in the dedicated WuXi Biology and Testing laboratory help advance drug development for a wide range of ophthalmic indications. Our services include:

Comparative ophthalmologic examination across a variety of ocular studies, including eye irritation, new ocular drug toxicity and toxicokinetic (TK), PK, and PD
Single- and repeat-dose ocular toxicology studies, conducted across a variety of species and via various dosage routes, including systemic, topical, subconjunctival, intracameral, intravitreal, sub-retinal, suprachoroidal, and retrobulbar

Comparative Ophthalmology

For general toxicity studies, scientists on our comparative ophthalmology research team study the ophthalmological toxicity of rodents, rabbits, canines, Non-human Primates (NHPs), and humans using slit-lamp and indirect ophthalmoscopy to examine the anterior and posterior segments of the eye, getting high-quality results.

Ocular Pharmacokinetics (PK)

Using state-of-the-art evaluation techniques, ocular PK studies assess tissue distribution and pharmacokinetics caused by ocular or systemic administration, and can be conducted across a variety of species, tissues and liquids.

Eye Tissue Dissection

Conjunctivae
Cornea
Iris/ciliary body
Lens
Retina/choroid
Sclera
Optic nerve

Liquid Sampling

Tear
Aqueous humor
Vitreous humor
Blood, plasma and serum

Evaluation Method

LC-MS/MS
Enzyme-linked immunosorbent assay
Immunohistochemistry

Ocular Pharmacodynamics (PD)

Ocular PD studies assess the efficacy of new ocular drugs via more than 30 animal disease models, with additional services available to support cell- and gene-therapy drug development. While new models can be developed to meet your specific needs, following are the main animal models available in-house: