End-to-End Program Management
Drug discovery programs require coordinated scientific planning across chemistry, biology, DMPK, pharmacology, bioanalysis, and safety assessment. WuXi Biology and Testing’s integrated drug discovery program management approach brings these capabilities together to support efficient execution, informed decision-making, and progression toward key development milestones.
We collaborate closely with our global customers, spanning pharma, biotech, and academia, to rapidly advance programs towards key inflection points and milestones by leveraging peer-recognized expertise and an integrated platform from hit identification through preclinical candidate selection and beyond.
Integrated Chemistry and Biology Research Platform
Our scientists provide drug discovery services and tailored solutions to advance your drug candidate selection in multiple disease areas. Through comprehensive discovery and technology platforms, peer-recognized scientific leadership and expertise in oncology, immunology, infectious disease, neurosciences, fibrosis, cardiovascular, and metabolic disease, our teams work collaboratively to rapidly advance programs from target to preclinical selection and beyond.
Integrated Drug Discovery Services for New Chemical Modalities
Our experts provide integrated solutions to global pharma and biotech for challenging targets. We deliver synthetic and medicinal chemistry solutions, and biology services for creating, identifying, and supporting preclinical candidates, from discovery to development.
Hit Identification
- Biological Science
- Target validation
- in vitro hit finding
- DNA-Encoded Libraries
- High quality protein production
- Fragment screening and biophysical hit finding
- X-ray crystallography
- CADD
- Discovery Chemistry
- Reference compounds
- Unique scaffolds, building blocks
- Customized screening decks
- SAR generation
- Molecule design
- Building blocks
Lead Optimization
- In Vitro and In Vivo Biology
- in vitro SAR support
- Selectivity and cell panel
- in vivo target engagement
- Safety pharmacology
- Efficacy and Toxicology studies
- PK/PD analysis
- Medicinal Chemistry and Synthetic Chemistry
- SAR generation
- Molecule design
- Building blocks
- Optimization of hits and leads
- Data interpretation
Candidate Selection
- Preclinical Biology
- Safety profiling services
- Ligand binding
- Receptor profiling
- Additional in vitro and in vivo characterization
- Chemistry Services
- Scale up of candidates for preclinical studies
- Synthetic optimization of candidates
- Metabolite and impurity identification synthesis
- Clinical l – lll
- PDX
- Tumor TILs
- Biomarkers
- CAP-certified FACS, pathology, molecular testing
- Analytical Services
Integrated Scientific Program Management
Our program management teams coordinate scientific and operational activities across chemistry, biology, DMPK, pharmacology, bioanalysis, and safety assessment. By working closely with customers and subject matter experts, they help establish program objectives, define study plans, align timelines and milestones, monitor progress, and facilitate cross-functional data review.
As new data emerges, the team supports interpretation of results, identification of development risks, and adjustment of study strategies when needed. This coordinated approach helps maintain alignment across functions and supports informed decision-making from hit identification through preclinical candidate selection and IND-enabling development.
- Integrated planning across scientific functions
- Defined objectives, timelines, milestones, and deliverables
- Regular communication and cross-functional data review
- Identification of scientific risks, gaps, and dependencies
- Flexible study planning based on emerging data
Hit Identification
- Target validation
- HTS- novel/focused libraries
- DNA-Encoded Libraries
- High quality protein production
- Fragment screening and biophysical hit finding
- X-ray crystallography
- CADD (molecular docking, homology modeling, pharmacophore modeling, core hopping, virtual screening)
Medicinal Chemistry and Synthetic Chemistry
- Medicinal chemistry design
- Synthetic chemistry- special chemistry platform, unique scaffolds/ building blocks, high throughput synthesis/ purification
- Large scale SFC/chiral separation. Impurity isolation and identification
- Program management
- Compound management
- Deliver preclinical candidates
- Learn More about Medicinal & Synthetic Chemistry
In Vitro Biology and In Vivo Pharmacology
- Multiple biology screening platform
- Infectious disease platform
- Specialty models including MASH
- Targeted oncology, immuno-oncology, translational oncology
- Autoimmune and inflammatory diseases
- Electrophysiology
PK | PD
- In vitro and in vivo ADME
- Preformulation
- Bioanalytical method development
- Multiple species
- PD models
- In vivo PK/PD (Biomarkers)
- Metabolite ID
- Radiolabeled studies
- Mass Balance
- Discovery to IND-enabling (US regulatory agencies, CFDA, EMA)
Toxicity Testing and Early Toxicology
- Non-GLP and GLP
- Safety pharmacology
- Genetic & in vitro toxicology
- Developmental & reproductive toxicology
- Ocular toxicology
- Toxicokinetics & bioanalytical analysis
- Pathology
Partnering With Us
- Track record of delivery, leadership and scientific excellence
- A comprehensive and integrated portfolio of discovery services
- >7,000 scientists across chemistry, analytical and biology
- Cost-effective, scalable solutions delivering quality data
- Global footprint with operations in North America, Asia and Europe
- Established IP protection policies and procedures. Seamless pathway from our discovery platforms to our development platforms
Related Services
Explore the scientific capabilities that support every stage of your drug discovery program. Our integrated service portfolio helps streamline development from target identification through IND-enabling studies.
Discovery Biology
Discover biology solutions that validate targets, identify hits, and generate the efficacy data needed to advance drug candidates.
Learn More
DMPK
Optimize candidate selection with integrated in vitro and in vivo ADME, pharmacokinetics, metabolism, and PK/PD studies.
Learn More
Bioanalysis
Support drug discovery and development with robust bioanalytical methods, biomarker analysis, and quantitative assays.
Learn More
Safety Assessment
Reduce development risk with integrated toxicology, safety pharmacology, genetic toxicology, and pathology services.
Learn More
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Discuss Your Program with Us
Share your development goals and key challenges with our experts to define the right path forward.
Frequently Asked Questions
End-to-end program management provides a single point of coordination across every stage of drug discovery, from target identification and hit discovery through lead optimization, DMPK, safety assessment, and candidate selection. This integrated approach improves communication, reduces delays, and helps accelerate development timelines.
We support discovery programs for small molecules and a broad range of emerging therapeutic modalities across multiple disease areas, including oncology, immunology, infectious diseases, neuroscience, cardiovascular, metabolic disorders, and fibrosis.
Yes. Our integrated platform supports programs from target validation and hit identification through lead optimization, preclinical candidate selection, and IND-enabling studies. Customers can engage individual services or leverage a fully integrated discovery program.
WuXi Biology and Testing combines extensive scientific expertise, dedicated program management, and a comprehensive portfolio of discovery and development services within one integrated platform. This approach helps customers improve efficiency, simplify project management, and accelerate the path toward preclinical candidate selection and beyond.