In Vitro Pharmacology and Safety
Identify Pharmacology and Safety Liabilities Early
Early identification of off-target pharmacology and safety liabilities can help inform candidate selection and reduce downstream development risk. Our in vitro pharmacology and safety capabilities include selectivity profiling, cell-based toxicity assessments, and electrophysiology studies to characterize compound specificity and identify potential safety signals during drug discovery.
Using scalable screening platforms and physiologically relevant cellular models, these studies can support candidate optimization and help determine which compounds should progress to more advanced preclinical evaluation.
Selectivity Evaluation
Off-target interactions can introduce unwanted side effects and clinical safety liabilities. Our broad selectivity profiling panels evaluate candidate activity across GPCRs, kinases, enzymes, transporters, and nuclear receptors. Through rigorous target screening, we help you confirm specificity and de-risk your lead molecules early in drug discovery.
In Vitro Cellular Toxicity Assays
Early assessment of cell viability can help identify cytotoxic liabilities and understand their potential cellular mechanisms. Our screening platforms use primary cell lines and immortalized cell lines with readouts that can assess cell viability, mitochondrial function, membrane integrity, and other cellular responses. These studies can help identify cytotoxicity and organ-specific safety signals early in candidate optimization.
Electrophysiology
Unintended modulation of ion channels can drive severe cardiac and neurological safety liabilities. By integrating high-throughput automated patch-clamp screening, manual electrophysiology, and multielectrode array, we evaluate target kinetics and off-target risks These studies can help identify off-target ion-channel effects and assess potential cardiac electrophysiology risks during candidate optimization.
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