In Vivo Autoimmune Disease Models | WuXi Biology & Testing

Disease-Relevant In Vivo Models for Immune Research

In vivo autoimmune and inflammatory disease models help determine whether therapeutic activity observed in in vitro assays translate into efficacy in animal models. WuXi Biology and Testing supports disease-relevant models spanning autoimmune arthritis, neuroinflammation, gastrointestinal inflammation, dermatologic disease, respiratory inflammation, systemic inflammation, and other immune-mediated conditions.

Study designs can be tailored to therapeutic mechanism, disease biology, and preclinical development stage, with endpoints such as clinical disease scores, cytokine and chemokine profiles, immune-cell phenotyping, histopathology, tissue biomarkers, and pharmacodynamic readouts. These data support efficacy assessment, mechanism-of-action evaluation, candidate selection, and preclinical decision-making.

Autoimmune and Inflammatory Disease Animal Models

Selecting an appropriate autoimmune or inflammatory disease model requires alignment between the therapeutic mechanism, the biology represented by the model, and the endpoints needed to answer the study question. Our portfolio includes acute and chronic models across neurological, musculoskeletal, dermatologic, gastrointestinal, respiratory, and systemic immune-mediated diseases, with customized efficacy and pharmacodynamic assessments.

Neuroinflammation and Experimental Autoimmune Encephalomyelitis (EAE) Models

Experimental autoimmune encephalomyelitis (EAE) models reproduce distinct patterns of immune-mediated CNS inflammation and demyelination and can be selected according to the desired acute, chronic, or relapsing-remitting disease course.

Myelin Oligodendrocyte Glycoprotein (MOG35-55/MOG1-125) induced EAE model
Myelin Basic Protein (MBP) induced EAE model
Proteolipid Protein (PLP139-151) induced relapse-remitting EAE model

Dermatologic Disease

Dermal inflammation models support evaluation of therapies targeting T-cell-mediated hypersensitivity, psoriasis, and atopic dermatitis, with study endpoints selected to reflect disease severity, inflammatory signaling, and tissue pathology.

Atopic Dermatitis (AD)
Psoriasis
Delayed Type Hypersensitivity (DTH)
Pruritus
Alopecia
Vitiligo

Gastrointestinal Disease

Inflammatory bowel disease (IBD) models support efficacy and mechanism studies for ulcerative colitis and Crohn's disease, with model options representing acute, chronic, chemically induced, and immune-mediated intestinal inflammation.

Inflammatory Bowel Diseases model (IBD)
Irritable Bowel Syndrome (IBS)
Pancreatitis
Gastric Ulcers/Diarrhea/Constipation

Pulmonary Disease

Respiratory inflammation models enable evaluation of allergic, acute inflammatory, and fibrotic mechanisms in the lung and upper airway, with model selection based on the intended therapeutic mechanism and disease phenotype.

Pulmonary Fibrosis
Asthma
Acute Lung Injury
Chronic Obstructive Pulmonary disease (COPD)
Rhinitis
Pulmonary arterial hypertension (PAH)
Cough

Acute Inflammation

Acute inflammation models support efficacy and mechanism studies for rapid-onset immune responses and cytokine storms, such as sepsis, and localized edema, with model options representing pathogen-induced (e.g., LPS), chemically triggered, and localized acute inflammatory pathways.

Cytokine Production
Sepsis
Peritonitis
Ear/paw Edema
Passive Cutaneous Anaphylaxis (PCA)

Rheumatic Disease

Rheumatic disease models support evaluation of therapies targeting autoimmune joint destruction, rheumatoid arthritis, and osteoarthritis, with study endpoints selected to reflect clinical arthritis scores, localized inflammatory signaling, and structural joint/cartilage pathology.

Rheumatoid Arthritis (RA)
Osteoarthritis
Psoriatic Arthritis
Gout
Ankylosing Spondylitis

Systemic Disease

Systemic disease models support evaluation of therapies targeting multi-organ autoimmunity, systemic lupus erythematosus (SLE), and systemic sclerosis, with study endpoints selected to reflect autoantibody profile, systemic inflammatory signaling, and multi-organ tissue pathology.