X-Ray Crystallography

Structure Determination with X-Ray Crystallography

X-ray crystallography remains a cornerstone of structure-based drug discovery, providing atomic-resolution insights into key interactions. At WuXi Biology and Testing, we deliver comprehensive crystal structure determination services to support every stage of drug development from initial hit finding to advanced lead optimization.

As a gold-standard laboratory testing partner, our scientific teams draw on over 15 years of experience solving challenging macromolecular structures. We offer flexible service models ranging from pre-established, disease-relevant targets to fully customized de novo structural workflows.

Protein Structures

XPRESS Target Portfolio

For rapid structural characterization, we maintain an extensive repository of pre-established, disease-relevant target proteins with optimized expression, purification, and crystallization conditions.

Our XPRESS platform provides immediate access to complex co-structures with your proprietary compounds, significantly accelerating turnaround times. Our available target library of 150+ disease-relevant targets covers critical disease pathways, including:

Kinases & Signaling: ABL1, ALK-1, B-Raf, BTK, EGFR, FLT-3, JAK1, KRAS, SOS1
Immuno-Oncology & Enzymes: STING, PARP-1, CYP3A4, and many others

Our average turnaround time is two months. Contact our team to review our complete, expanding target portfolio or request a detailed proposal for your specific target of interest.

XPEDITE Rapid-Access Structural Support

When your target protein of interest has published structural precedents but requires customized construct generation, our XPEDITE service offers rapid, reliable access to high-resolution complex structures with your proprietary ligands.

Program Benefits & Scope:

Published Construct Reproduction: Rapid generation of established target constructs and optimized crystal systems.
Mutational Variant Profiling: Access to structures featuring disease-relevant mutations, drug-resistant variants, or personalized medicine targets to elucidate molecular mechanisms of action.
Streamlined Timelines: Initial protein production and system setup within 8–12 weeks, followed by an average 8-week turnaround time for subsequent co-crystal structures.

XPERT Customized Solutions for Challenging Targets

For complex biological targets, unconventional modes of action, antibody-antigen complexes, or de novo structures without published precedents, our XPERT model provides fully customized structural biology programs.

Our expert scientific teams work directly with you to establish milestone-driven research blueprints supported by flexible, performance-based delivery schedules. Leveraging decades of structural expertise across more than 200 distinct target classes, we successfully solve complex structural challenges, including: