Supporting Discovery of mRNA Drugs

Unlike conventional protein-targeted therapies, which often provide only transient effects, nucleic acid therapeutics have the potential for long-lasting effects and greater target specificity. In recent years, the potential of mRNA therapies has been well demonstrated. However, the development of mRNA drugs faces numerous challenges, including reducing immunogenicity, improving stability, enhancing in vivo delivery efficiency, and achieving appropriate biodistribution.

To address these challenges, WuXi Biology has established an integrated mRNA drug discovery platform with services that include:

• mRNA sequence design and optimization
• mRNA synthesis and formulation
• Assessment of mRNA delivery systems
• In vitro expression and functional validation
• In vivo efficacy and biodistribution
• Early safety evaluation