Screening Strategies for Molecular Glue Discovery

Molecular glues are molecules that can encourage two proteins to interact when they otherwise may not. As a consequence, they can induce proximity to help stabilize existing interactions or create new, nonnative interactions. These interactions could lead to degradation, stabilization, inhibition, or activation of the target protein, ultimately resulting in the desired therapeutic outcome.

Molecular glues show great potential for treating diseases such as cancer and infectious, inflammatory, and neurodegenerative diseases. In this white paper, we provide an in-depth perspective on strategies crucial for accelerating research focused on the development and optimization of these unique molecules. Topics include molecular glue screening methods, binding assays, functional assays, and in vivo pharmacology.